(2004) Journal of Peptide Research Meta-analysis of safety data from multiple AOD 9604 trials examining injection site reactions, systemic AEs, and tolerability

Technique Ultrasound-guided approach (preferred) Local Corticosteroid Injection at tendon sheath under Ultrasound guidance (see Shoulder Ultrasound) Approached in-plane to linear Ultrasound probe (probe short axis to anterior Shoulder - home position) Do not inject within tendon (and avoid circumflex artery within groove) Technique Landmark-based approach Images Landmarks Identify bicipital tendon in bicipital groove (proximal Humerus) Mark point of maximal tenderness over groove Injected with sterile technique (with Betadine preparation of skin) Direct needle parallel to bicipital groove (vertically oriented) Needle enters skin at 30 degrees oriented superiorly Do not inject bicipital tendon Infiltrate area around groove, but not into tendon Flow resisted when needle is inside tendon Withdraw needle slightly and retry Continue to withdraw until not in tendon Complications Bicipital tendon rupture Associated with intratendinous injection Do not inject bicipital tendon References

It is not approved by the FDA for veterinary use and should not be administered to animals outside of approved research protocols
Research documents a 70% increase in collagen production in treated women compared to controls, outperforming both vitamin C and retinoic acid in comparative trials
Animal studies report accelerated tissue repair and decreased scarring after injury to the reproductive tract
This combination is widely studied in laboratory settings for synergistic effects on tissue repair, recovery, and regenerative pathways