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Hum Genomics

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Indications: FDA : Topical anesthesia of the upper respiratory tract (due to its combined vasoconstrictor & local anesthetic properties) Off Label : Use in Emergency Department as one ingredient in a topical anesthetic solution called TAC (containing: Tetracaine, Adrenaline & Cocaine) that is applied to a wound prior to cleaning & suturing Contraindications: Hypersensitivity to ester anesthetics Side Effects: Acute signs of systemic toxicity include can include multiple signs of both CV & CNS stimulation: tachycardia hypertension hyperthermia mydriasis seizures cardiac arrhythmias (multiple contributing variables: Na & K channel block, possible coronary vasoconstriction) Acute effects associated with cocaine abuse

Research & Development (R&D) This initial stage involves discovering and developing GLP-1 peptide molecules with the potential for effective weight loss

For borderline resectable and locally advanced, unresectable tumours, neoadjuvant protocols are utilized, with a shift towards chemotherapy rather than radiochemotherapy, although good evidence from randomized controlled trials is lacking

The ABCG2 Q141K hyperuricemia and gout-associated variant illuminates the physiology of human urate excretion