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Finally, it is known that this deciency depended on age and was more pronounced in older people

Under these conditions, the colored complex remains stable over time

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A 2025 narrative review in Current Reviews in Musculoskeletal Medicine identified only three published human studies: Lee & Padgett (2021) on knee pain (n=16), Lee et al

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Studies have shown that pulmonary plasmacytoid dendritic cells (pDCs) and CD8(+) dendritic cells promote the survival and accumulation of T cells in the lung, and the absence of pDCs/CD8(+) DCs leads to extensive apoptosis of CD8(+) T cells in the lung 7,8