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Clinicians should not treat weight loss and glycemic control as separate goals

Isolated islets from another mouse model with -cell KO of PC1/3 had reduced levels of GLP-1 in the islet and reduced glucose-stimulated insulin secretion (227)

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At the same time, there are important considerations to keep in mind, especially if you plan to take these medications long-term

GLP-1 and Adjusting Your Diet Correctly: Protecting Muscle and Metabolism Using a GLP-1 medication