Excess weight around the neck creates fatty deposits that narrow airways, while abdominal weight compresses lungs and decreases airflow 35
Originally developed for the treatment of type 2 diabetes, they have been approved by the FDA for weight management in adults with obesity or overweight conditions with related health issues
The result is often worse nausea, bloating, and discomfort than either the injection alone or the food alone would have caused
Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, though these medications are often collectively referred to as incretin-based therapies
LY2189265, a longacting glucagonlike peptide1 analogue, showed a dosedependent effect on insulin secretion in healthy subjects
Long-term data beyond a few years is still being collected, and doctors continue to monitor for rarer risks as more people stay on these medications for longer periods
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