Conversely, inhibition of cytosolic GAPDH (cGAPDH) by cyclo(His-Pro) redirects carbon flux from glycolysis to the pentose phosphate pathway (PPP), enhancing nicotinamide adenine dinucleotide phosphate (NADPH) production and antioxidant defense, which is vital for mitigating oxidative stress (Minen et al., 2025) ( Figure 6 )
doi: 10.1038/s41586-019-1836-5 193 KurtulusSMadiAEscobarGKlapholzMNymanJChristianEet al
This work is supported by the National Science Foundation of China (NO.82374048 to FL, No.82304366 to LJ)
Sci Rep 15 , 19127 (2025)
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective
Hinge, like the angiotensin IV antagonist Norleual, was established as a c-Met antagonist by its ability to block HGF-dependent c-Met phosphorylation and prevent HGF-dependent scattering in the MDCK epithelial cell line