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Interestingly, MOTS-c interact with STAT3 via the YIFY region to reduce STAT3 transcriptional activity, which enhances myotube formation, suggesting that MOTS-c have a diagnostic and therapeutic promise for muscle-wasting and other energy-deficient muscle illnesses [33]

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[149] The few studies that have used equivalent (weight-adjusted) human therapeutic doses and oral administration show that these changes, if they occur, are relatively minor

Social influences on neuroplasticity: stress and interventions to promote well-being

Generally yes, especially in the 5002000 mg range depending on the product