In some embodiments, the otic formulation or composition comprises between about 0.01% to about 80% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
Test Subjects (n = 72): Average age of the subjects was 20-70 years old Diagnosed with type 2 diabetes for at least 3 months prior to enrollment No glucose-lowering medications were allowed within 3 months before the trial started (except for Metformin, in which case the dose had to be unchanged) Body mass index (BMI) of 23-50 kg/m, with bodyweight remaining stable ( 1000mg of Metformin daily or (b) undergone a diet and exercise treatment alone Bodyweight had to be within +/- 5kg for 3 months prior to randomization Dosing Schedule: Patients were randomly assigned to the following groups for 36 weeks in a 2:2:2:1:1:1:1:2 ratio, followed by a safety follow-up period of 4 weeks Group #1 = Placebo Group #2 = 1.5mg Dulaglutide injected subcutaneously once a week Group #3 = 0.5mg Retatrutide injected subcutaneously once a week Group #4 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 4mg Group #5 = 4mg Retatrutide injected subcutaneously once a week Group #6 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 8mg Group #7 = 4mg Retatrutide injected subcutaneously once a week, with dose escalation to 8mg Group #8 = 2mg Retatrutide injected subcutaneously once a week, with dose escalation to 12mg Retatrutide dose was increased every 4 weeks where applicable (i.e
elegans germline development (Subramaniam and Seydoux, 2003
Lee YH, Kim JH, Kim SR et al (2017) Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
placebo), most of them (liraglutide, semaglutide SC, dulaglutide, albiglutide, and efpeglenatide) have also demonstrated a reduction in MACE with respect to placebo, while weekly exenatide or oral semaglutide showed a tendency to reduce MACE
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