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Targeted therapies are another popular form of systemic therapy, in which molecular drivers of tumor progression are selectively targeted

S., Hafez, M

In the mevalonate pathway, the enzyme 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, which converts HMG-CoA into mevalonate, is common to the biosynthetic pathways of both coenzyme Q 10 and cholesterol and is inhibited by statins (cholesterol-lowering drugs

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Compared with free drugs, the bioavailability of FU002 encapsulated in CPP-GCTE liposomes was significantly increased by approximately 438%, showing a significant promotion effect of CPPs in oral delivery (Werner et al., 2024)

No adverse effects were noted in clinical trials (ulcerative colitis, phase II), and in toxicological studies, a lethal dose (LD1) could be not achieved (for review see [1,2,3,4,5,6,7,8,9,10,96,97,106,107,193])