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Hexarelin: Maximum Potency, Broad Effects Hexarelin produces the strongest acute GH release of any GHRP: GHS-R1a Activation: High-affinity binding produces powerful GH release Cortisol Release: Significant ACTH and cortisol elevation (stress hormone activation) Prolactin Elevation: Increases prolactin levels, potentially problematic for some applications Appetite Stimulation: Moderate ghrelin-like hunger effect Cardiac Activity: Unique cardioprotective effects through cardiac GHS receptors Desensitization: Rapid tolerance development

[86] As of 2005, recombinant growth hormones available in the United States (and their manufacturers) included Nutropin (Genentech), Humatrope (Lilly), Genotropin (Pfizer), Norditropin (Novo), and Saizen (Merck Serono)

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Meier JJ, Gallwitz B, Siepmann N, Holst JJ, Deacon CF, Schmidt WE, Nauck MA