GCEE may react directly with ROS due to the cysteine residue and/or increase GSH, which can protect against ROS and nucleophilic compounds
reported reduction in myocardial infarct size and prevention of deteriorated cardiac function on exanatide treatment in porcine model of ischemia/reperfusion [58]
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Glutathione supplementation does not alter tirzepatide pharmacokinetics, but NAC in high doses (above 1800mg daily) can affect cysteine-dependent metabolic pathways that influence insulin sensitivity, which may interact with tirzepatide's glucose-lowering effects in patients with type 2 diabetes
As for its role in protein synthesis, tryptophan is a precursor of crucial metabolites, such as 5-HT, which plays an essential role in functional gastrointestinal diseases (Heitkemper et al., 2016)
Estrada LV, Watman D, Franzosa E, Reckrey J