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Tran CD, Ball JM, Sundar S, Coyle P, Howarth GS

In real-world scenarios, the trade-off between effectiveness and side effects becomes clear

HA-344 and #231 as dual inhibitors of GPX4 and TXNRD1 in AML cells In the same line, we recently designed two covalent small molecule inhibitors, that can concomitantly inhibit GPX4 and TXDNR1, two critical proteins involved in the protection of cell from ferroptosis and apoptosis [39]

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Severe hypersensitivity reactions, including anaphylaxis, have been reported, and the medication should be discontinued if this occurs