The presence of obesity-related complications such as obstructive sleep apnea, metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), or cardiovascular disease may justify longer treatment duration given the health benefits of sustained weight loss
A recent New England Journal of Medicine study showed that although both these new drugs are highly effective, tirzepatide was shown to be more effective for weight loss, possibly because of the combination of these two hormone agonists when compared to the single hormone agonist in semaglutide
2024 Feb 16;446:138739
Oprah stepped down from WeightWatchers board in early 2024, just as the company began reinventing itself for the modern era of weight loss
Sources Wajdlich, M., & Nowicki, M
Slows Gastric Emptying: GLP-1 slows down the rate at which food leaves the stomach