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This delayed gastric emptying contributes to improved post-prandial (after-meal) glucose control and promotes satiety, which may lead to weight reduction, although Ozempic is not licensed for weight management in the UK

However, leptin serum levels are chronically increased in individuals with obesity, resulting in leptin resistance similar to insulin resistance also observed in obesity, which can result in a loss of its antisteatotic effects [32]

This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety

Nitric oxide synthase (NOS) requires NADPH as a cofactor to produce NO

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