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Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose-response meta-analysis

Dual therapy (initial combination or stepwise approach) is more potent than either monotherapy in patients treated with diet and exercise or already treated with metformin

Some patients may experience mild nausea, injection site soreness, or temporary body odor changes

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doi: 10.2188/jea.JE2007417

Symptoms of gastroparesis include persistent nausea and vomiting that does not resolve, severe abdominal pain and bloating, inability to eat or keep food down, significant weight loss from malnutrition, and in the worst cases, the need for hospitalization, feeding tubes, or surgical intervention