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Sirt1, Sirt6 and Sirt7 are predominantly localised in the nucleus, while Sirt2 is found in the cytoplasm, and Sirt3, Sirt4 and Sirt5 are found in the mitochondria ( Sirt1 and Sirt2 are crucial for mitochondrial biogenesis ( Dysregulation of Sirts, particularly Sirt1, Sirt2 and Sirt3, has been linked to mitochondrial dysfunction, oxidative stress, and neurodegeneration in PD