(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)
Fluorescence imaging of GSH Normal thyroid Nthy-ori 3 1 cells were used as negative control, lung cancer H1299 cells were used as positive control, and two kinds of ATC cells were treated with AP probe-net to evaluate GSH levels
Natural inhibitor found for cell death by ferroptosis
Multi-year cohort data supports sustained VAT reduction with continued administration
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Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial