Phase I reactions (primarily oxidation, reduction, and hydrolysis) structurally modify the parent compound but frequently generate reactive intermediates that can be more cytotoxic than the original molecules
35 Within the kidneys, there are 2 salient SGLTs: SGLT-1 and SGLT-2
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Chem Phys Lett 676:3945
Importantly, 68% remained adherent to the programme after one year, with significant improvements in cholesterol, blood pressure, quality of life, sleep quality, energy levels, and mental health