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Conversely, it has been suggested that the ER membrane might be permeable to small molecules such as GSH (but not GSSG), allowing transport to occur by diffusion (Le Gall et al , 2004)

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

[12] More recently, though, the following data was submitted: IC 50 (nM) NET 1.7, SERT 11, DAT 65.[ [13] cited in [14] ] The revised IC 50 's would adequately explain the lack of efficacy in treating Parkinson's disease, i.e

10.1186/s12866-017-1027-1 30 KuK.-M.KimM

Rosenfeld CR, Cox BE, Roy T, Magness RR