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Furthermore, the KDIGO 2024 guidelines cover combination therapy from the perspective of SGLT2is being first-line therapy, and long-acting GLP-1 RAs being an add-on in adults with CKD and T2D who have not achieved individualised glycaemic targets despite use of metformin and SGLT2is, or who are unable to use those medications [2]

Promotional Practices and Advertising Scrutiny In addition to productliability claims and compounding enforcement, promotional practices are a growing source of legal and regulatory exposure in the GLP1 space, especially as these therapies remain highvisibility and are frequently marketed through telehealth, subscription programs, and directtoconsumer channels

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The challenge of a 2-year follow-up after intervention for weight loss in primary care

Semaglutide is not a rapid-acting medication

While sommarutide is undoubtedly an exciting potential treatment option, there is still a lack of clear clinical data on the mechanism of action of GLP-1 agonists in NASH, such as whether GLP-1 agonists have a direct, independent role in improving NASH, or simply by improving body weight, insulin resistance, and so on