Our results show that glutathione efflux from hepatocytes results in high local concentrations of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface chemistry, reduces its affinity to serum protein and significantly alters its blood retention, targeting and clearance
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There's no first-pass metabolism issue, no gut enzyme exposure, no uncertainty about what percentage of the dose actually reaches target tissue
Archived from the original on 11 January 2020
For Neely, the experience was a remarkable microcosm story that vaccines work. It also highlighted for him just how time- and resource-intensive it can be to conduct contact tracing and other work to manage a measles outbreak work that health departments across the country has been heavily immersed in