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In addition, upregulation of inflammation-related genes COX-2 (cyclooxygenase 2), IL-1 , and GFAP (glial fibrillary acidic protein) and downregulation of AChE (acetylcholinesterase) expression were detected

Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial antioxidant transcription factor

In the CNS, ammonia is theorized to cause inflammation, oxidative injury, astrocyte swelling, increased NMDA activity, and osmotic stress which can all lead to brain injury and cerebral edema

It helps recycle oxidized glutathione back into its active form, allowing the body to maintain higher antioxidant protection

Yeste-Velasco, M., et al

LOX-mediated peroxidation of PE-PUFA generates lipid hydroperoxides (PE-AA/AdA-OOH) and hydroxyl radicals (OH), key ferroptosis executioners