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109 This underscores the fact that mechanical input is not merely a function of movement frequency, but also of the magnitude and direction of the applied force

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2, in c-Met signaling, overexpression of the c-Met receptor and HGF results in sustained PI3K/Akt/mTOR and MAPK signaling activation through Gab1 and mutation of MET kinase domain, which are associated with therapy resistance [87]

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