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579,666 Ramified astrocytes with tau depositions in soma and in processes are the histopathological hallmark of the Picks disease

However, largescale randomized trials have not demonstrated tumor shrinkage, longer survival, or consistent symptom relief, so the clinical benefit remains uncertain

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The etiology of goiter is complex and can occur in individuals with euthyroid, hyperthyroid, or hypothyroid states (Knobel 2016)