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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

Firstly, asymptomatic patients of NYHA I class display significantly deficiency in blood glutathione level compared to healthy controls

The decreased expression of TF in oligodendrocytes in the SN of PD patients may decrease the ability of oligodendrocytes to sequester excess iron, ultimately resulting in an increase in oxidative stress in dopaminergic neurons