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Studies suggest it may modulate neurotransmitter systems by normalizing the activity of the enzyme AchE, thereby potentially influencing levels of the neurotransmitter acetylcholine (Oladapo et al., 2021)

[DOI] [PubMed] [Google Scholar] 135.Ivanov A.V., Valuev-Elliston V.T., Ivanova O.N., Kochetkov S., Starodubova E.S., Bartosch B., Isaguliants M.G

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In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig