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Psychopharmacology (Berl), 180 (3), 473490

Nat Rev Mol Cell Biol 12(1):914 Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I (2015) Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

That does not mean recovery is impossible

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Additionally, individuals who used e-cigarettes for longer than three years not only exhibit reduced microvascular function but also diminished macrovascular dysfunction, implying that those who use the product for a longer time are at risk of systemic vascular effects [128]

You may also want to consider sleeping with a humidifier in your room if your dry mouth tends to be caused from sleeping with your mouth open