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Halitosis, more commonly known as bad breath, affects approximately 35% of people worldwide and 80 million people in the United States

Most patients report noticeable appetite regulation within the first two to three weeks, with visible body composition changes developing over the following months

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If cellular assays are predictive of potential toxicity, the use of animal models allows the evaluation of toxicity signs occurring in response to the gradual increase in the dose of the substance, considering that the biological response could be species-specific and an active ingredient in animals could be completely inactive in humans

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Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development