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Additionally, when mtDNA leaks into the extracellular space from endothelial cells and vascular smooth muscle cells, it can inhibit angiogenesis and wound healing or promote vascular calcification by activating the cGAS-STING-IRF3 signaling pathway, potentially contributing to vascular lesion development [265]

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This random coil transition is associated with an increase in absorbance at 260 nm, referred to as the hyperchromic effect [ 117 ]

10.1016/j.jsbmb.2003.10.007 25 Capelli-SchellpfefferM.GerberG

Allergic reactions including rash, swelling of the face or throat, or difficulty breathing

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