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As B12 is a water-soluble vitamin, it's generally considered safe (because any not used will be excreted via your urine), but even so you shouldn't take more than the recommended doses unless recommended to do so by your GP, as some studies have shown possible negative impacts of overdoing it

Who usually needs B12 shots

No , B12 usually has the opposite effect

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The process is simple: Complete a medical questionnaire

[137] Laboratory [edit] The complete laboratory synthesis of B 12 was achieved by Robert Burns Woodward [138] and Albert Eschenmoser in 1972