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This is hugely important, as it is the main reason doctors are so worried about Downs syndrome and other chromosomal disorders that can occur in the offspring of women over 35

If the maximum recorded temperature exceeded 10C at any point, the vial's potency is suspect

PubMed Schauer, E., Wronski, R., Patockova, J., Kosla, K., Stoll, G., Fuchs, J., & Macho, L

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doi: 10.1007/s13300-017-0283-2 146