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Combining both remains well-tolerated when each is dosed conservatively and escalated gradually

Mitochondrial dysfunction, which leads to impaired oxygen, metabolism, has been speculated to play a role in migraine pathophysiology by influencing neuronal information processing, and migraine patients have been shown to have a reduction in mitochondrial phosphorylation potential between headaches

NIH

A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

10.1016/j.jneuroim.2015.05.007 Pubmed Abstract CrossRef Google Scholar View reference in article 40

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