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Additionally, the use of antiviral drugs helps to reduce viral load, which could mitigate the prolonged inflammation and immune dysregulation seen in many Long COVID patients [23,24]

In contrast, low stiffness increases the activity of the Ras-related GTPase RAP2 which inactivates RhoA and induces the phosphorylation of the large tumor suppressor kinase 1/2 (LATS1/2)

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Molecular chaperone functions in protein folding and proteostasis

Recent advances in single cell and nuclei RNA sequencing approaches greatly improved our understanding of cellular maladaptations in AT dysfunction and outdated the historical notion that only two macrophage subpopulations (M1 as pro-inflammatory and M2 as anti-inflammatory macrophages) exist 19,20