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Consider switching to insulin & other therapies Some patients established on GLP-1 RA therapy for type 2 diabetes may need to be switched to alternative treatments including insulin

Jia G, DeMarco VG, Sowers JR

More comprehensive human studies are needed to validate and fully understand these benefits

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The trade-off is precision: the smaller the microgram per IU, the more forgiving the syringe granularity, but the larger the injection volume per study event

The standard clinical titration schedule for melanotan-1, derived from Phase 2 trials of afamelanotide implants conducted by CLINUVEL Pharmaceuticals, follows a 710 day step-up pattern