This future combination should contain multiple targets and layers, including the control of TYR expression on transcription and protein levels, inhibition of enzymatic activity in the melanogenesis pathway, suppression of melanocyte proliferation and the transport of melanosomes on a cellular level
the primary differences being the location of deposition and/or the protein(s) that accumulate (Figure 196-1)
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2010;61(6):4828 Bankir L, Bouby N, Trinh-Trang-Tan MM, Ahloulay M, Promeneur D
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