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The approval was based on a series of studies, including a pivotal Phase III trial assessing the vaccines consistency, immunogenicity and safety in healthy adults

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Given the established role of ER as a transcriptional regulator of neurotrophins in the central nervous system, growing evidence suggests that this signaling module is functionally conserved and repurposed to drive malignancy within the ovarian tumor microenvironment [37]

[64], treatment with acetyl-l-carnitine (500 mg twice daily intramuscularly for 10 days followed by 2000 mg daily administered orally for 355 days) resulted in improvement in neurophysiological parameters and pain reduction over a 1-year period [64]