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Some patients find that remaining at a lower maintenance dose, whilst potentially sacrificing some glycaemic or weight loss benefits, provides an acceptable balance between efficacy and tolerability
GLP-1 receptor agonists like semaglutide and tirzepatide work through an entirely different mechanism: they activate incretin receptors in the pancreas and brain to reduce appetite, slow gastric emptying, and improve insulin sensitivity
Butler MG, Moore J, Morawiecki A, Nicolson M
Importantly, liking and wanting do not necessarily follow the same temporal pattern and may differ across individuals
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