This shift is underscored by recent findings that highlight the central role of context-dependent efficacy, whereby baseline nutrient status, genetic variability, and comorbid metabolic profiles critically determine clinical outcomes (Table 1
Although this lies beyond the scope of this study, it represents an important direction for future investigation
37,38 We assumed that benefits diminish with weight regain, reflecting the importance of sustained weight loss
Isolation work supplements these primary movements but should not replace them
These bioactives, when loaded into nanocarriers like SLNs and NLCs, exhibit enhanced dermal penetration, stability, and controlled release profiles compared to crude extracts, making them more comparable mechanistically to synthetic small-molecule inhibitors
E., Maguiness, K., Chmiel, J