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Minutes after initial stimulation, neutrophils switch from primarily using glycolysis for basal metabolism, to the PPP, in order to allow for rapid generation of NADPH ( Brisk production of NADPH through the PPP is itself linked to sufficient basal and reserve capacity of G6PD enzyme activity ( Figure 1A )

Enzymes like acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are central to incorporating PUFAs into membranes, sensitizing cells to ferroptosis (7173)

This boost delivered in a controlled setting can help promote balance

There is also the tantalizing idea that -fetoprotein may serve as a selective delivery system for estradiol to neurons (212), but definitive proof and regional specificity have not been demonstrated

Biochemistry., 2007, 72(7), 698-701

Adapted from Rumack and Matthews, Pediatrics 1975