Strengths and weaknesses of this review This systematic review and meta-analysis was registered and reported with PRISMA [21] and included the full of original trials whenever possible
Addressing the moderate heterogeneity, future studies are encouraged to include a larger number of trials with similar comorbidity profiles because this would increase homogeneity and improve the reliability of the results, while aligning efficacy estimates with mortality reduction observed within comorbidity subgroups
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In PIONEER 6, patients were randomized (1:1) to receive once-daily oral semaglutide or placebo, both in addition to standard care
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