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The master regulator of the cellular redox balance is the transcription factor Nrf2 (NF-E2-related factor 2) which induces target genes involved in cytoprotection such as thioredoxin reductase 1 (TXNRD1) or NAD(P)H quinone oxidoreductase 1 (NQO1)

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For instance, individuals with a BMI greater than 30 kg/m2 might benefit more from a well-organized weight reduction program prior to proceeding with surgery

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