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The radioactive compounds were ordered from ARC, and all experiments were performed in ND96 buffer (96 mM NaCl, 2 mM KCl, 1.8 mM CaCl 2 , 1 mM MgCl 2 , and 5 mM Hepes-NaOH, pH 7.4) at pH 7.4, except for the pH dependency assay at pH 5.5, 6.0, 7.0, 7.4, or 8.5

a process for preparing such a composition is also described in detail in CA 2,142,277

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The 28-day mortality rate was collected and calculated by follow-up of patients after intervention by telephone contacting their families

Reflective of the GLP-1RA class, gastrointestinal effects, including nausea, diarrhoea and vomiting, were the most common adverse events [12, 14,15,16,17, 29, 38]

Periodic treatment breaks are commonly recommended to prevent receptor adaptation and ensure continued responsiveness