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Baclofen, a GABA-B agonist, is the most studied non-FDA-approved drug in cirrhosis

The FDAs removal of boxed warnings on HRT products was a watershed moment

Water, L-carnitine, Inulin, Choline, Acidity Regulator (Phosphoric Acid), Natural Flavourings, Salt, Sweetener (Sucralose), Preservatives (Potassium Sorbate, Sodium Benzoate), Vitamin B5, Vitamin B6, Vitamin B12

Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue

The company built its proprietary Precision Endocrine Peptide (PEP) platform to engineer peptide hormones with extended time-action profiles, aiming to overcome the dosing-frequency and tolerability limitations of earlier peptide therapeutics, including in the obesity space

Inulin, and possibly other fermentable carbohydrates, could therefore represent a potentially effective intervention at the population level