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For Mounjaro, these include nausea (1229% of patients depending on dose), diarrhea (1216%), vomiting (59%), constipation (67%), and abdominal pain or discomfort

We were looking at these rodent studies, and were like, these look really promising. And were doing the math on species conversions to figure out human doses. Nobody was under the illusion that what they were doing was definitively safe, he continued

A stable oral form allows researchers to study its effects directly within the GI tract and investigate its systemic absorption more reliably, something that is very difficult with the acid-sensitive acetate form

Pharmaceutical interventions to slow human aging

10.1016/j.gene.2013.10.017 Gene

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