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Furthermore, the silencing of PKM2 decreases IL-1-stimulated elevated protein expression of matrix metallopeptidase (MMP)13 and PKM2 in primary chondrocytes and restores protein expression of type II collagen (COL2A1) ( In translated proteins, post-translational modification (PTM) occurs when amino acid side chains are covalently modified ( The MAPK signaling pathway has three branches, and its signal transduction is involved in cell apoptosis, cell proliferation, and cell differentiation (60)
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10.1074/jbc.271.37.22810 96 FeronO.SaldanaF.MichelJ
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