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Accumulated evidence suggests that increased TNF production plays a central role in the pathogenesis of NAFLD, especially in its progression to NASH

Exclusive Pharma Industry 4 min read After WHO nod, Indian Patient Groups urge GLP-1 inclusion in NLEM With the WHO recommending blockbuster GLP-1 therapies such as Semaglutide and Tirzepatide as essential medicines for diabetes, patient advocates in India are urging their inclusion in the National List of Essential Medicines (NLEM) to enable state procurement, free distribution, and wider affordability

Differential scanning fluorimetry (DSF) DSF was performed either by a dye-based method using a Lightcycler RT-PCR instrument (Roche) or label-free using a Prometheus NT.48 nanoDSF instrument (Nanotemper Technologies GmbH)

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We assessed the relationships between the GLP-1 RAs users and the control group concerning primary and secondary outcomes using the Cox proportional hazards model, which allowed us to calculate adjusted hazard ratios (aHRs) 51

Layering insights from different omics analyses in this way gives a fuller picture of the interactions between metabolites, proteins, genes and environmental factors that drive disease processes