, this collection explores what it means to think, feel, and connect in the modern world
Abbreviations 5-HIAA: 5-Hydroxyindoleacetic acid 5-HT: Serotonin (5-hydroxytryptamine) BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor cAMP: Cyclic adenosine monophosphate CRH: Corticotropin-releasing hormone CRP: C-reactive protein DPP-4: Dipeptidyl peptidase-4 GABA: Gamma aminobutyric acid GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like-1 peptide receptor GLP-1RA: Glucagon-like-1 peptide receptor agonist HPA: Hypothalamicpituitaryadrenal axis Icv : Intracerebroventricular Ip : Intraperitoneal IL-1: Interleukin-1 beta IL-6: Interleukin-6 NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NTS: Nucleus tractus solitarius PKA: Protein kinase A PPG: Preproglucagon PVN: Paraventricular nucleus SCFA: Short chain fatty acid T2DM: Type 2 diabetes mellitus TNF-: Tumor necrosis factor alpha VTA: Ventral tegmental area References Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, et al
& Tang, S
Conclusion GLP-1 medications have proven to be effective for management of diabetes as well as for weight loss in those without diabetes, especially when combined with a healthy diet and adequate exercise
Room temperature allowances before use (single-dose devices): Wegovy: Up to 28 days at temperatures up to 86F (30C) Trulicity: Up to 14 days at temperatures up to 86F (30C) Mounjaro/Zepbound: Up to 21 days at temperatures up to 86F (30C) After first use (multi-dose pens only): Ozempic: Up to 56 days at room temperature or refrigerated Victoza/Saxenda: Up to 30 days at room temperature or refrigerated In warmer climates or during summer months, patients should be particularly cautious about leaving pens in hot cars, direct sunlight, or near heat sources
And people need to exercise and do resistance training so they can be sure to maintain muscle mass
