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Concurrently, genetic and epigenetic profiling is being incorporated into large-scale prospective studies to further clarify gene-environment interactions, identify biologically vulnerable subgroups, and build individualized risk models 29

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9 In addition, His13 in Ab QueD2 (analogous to metal ligand His16 in Ec QueD) does not coordinate the Zn II and instead incorporates His 68, analogous to His71 in Ec QueD, one of the catalytic bases in the second half of the reaction

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Journal of digestive diseases 13 , 133142, doi: 10.1111/j.1751-2980.2011.00569.x (2012)