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Circadian clocks and cancer: timekeeping governs cellular metabolism

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About Ro weight loss At its core, the Ro Body membership is designed to make clinically guided weight loss more accessible and sustainable

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Carbohydrates High carbohydrate diets increase insulin activity and may therefore increase IGF-1, which acts a lot like insulin

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Oxidative damage impairs a cells capacity to proliferate and respond to stress in a normal fashion

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You should seek medical advice if you experience: Severe or persistent sore throat lasting more than a few days without improvement Difficulty swallowing (dysphagia) or pain when swallowing (odynophagia), which may suggest oesophageal inflammation or infection and warrants urgent referral to exclude cancer (in line with NICE guidance NG12) Breathing difficulties or stridor (a high-pitched sound when breathing) call 999 immediately as this could indicate airway obstruction or severe allergic reaction High fever (above 38C) accompanied by sore throat, which may suggest bacterial infection requiring antibiotic treatment Swelling of the face, lips, tongue, or throat call 999 immediately as this could indicate angioedema, a potentially life-threatening allergic reaction Persistent hoarseness or voice changes lasting more than three weeks Blood in saliva or phlegm If you suspect your throat symptoms are related to severe reflux or oesophagitis , particularly if accompanied by chest pain, difficulty swallowing, or unintentional weight loss, your GP may refer you for further investigation, such as endoscopy, in line with NICE guidance on dyspepsia and GORD

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