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In pancreatic cancer, the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene reprograms glutamine metabolism by upregulating aspartate transaminase (GOT1) and repressing GLUD1 to increase the NADPH/NADP(+) ratio for stable redox capacity (Son et al., 2013)

however, its severe liver and pancreatic toxicity restricted its clinical application (190)

Enzyme Microb Technol 26:737742 Penninckx MJ (2002) An overview on glutathione in Saccharomyces versus non-conventional yeasts

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Blood 109 , 38123819 (2007)

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